Much of the following information has been gathered from various sites about the internet as well as various newsgroup articles, emails, and personal documents. As such, I am unable to verify the accuracy of all of the information so be wary of what one takes from these pages. Please consult with a professional health care provider before doing anything suggested or implied.
Famciclovir (Famvir-SmithKline Beecham)
A large, multinational study showed that famciclovir (Famvir, SmithKline Beecham) was effective in treating chronic hepatitis B. Its safety profile was comparable to a placebo, according to a study presented at the American Association for the Study of Liver Diseases (AASLD).
Patients were selected at random before receiving either 16 weeks of famciclovir (500 mg, 250 mg or 125 mg) or placebo three times a day. Forty-one percent of patients failed to respond to interferon therapy prior to this clinical trial. Most had high HBV DNA levels (median 3,600 picograms) and the median ALT was low (1.7 times upper limit of normal range).
"Famciclovir treatment resulted in a rapid, dose-dependent suppression of hepatitis B virus replication. In all famciclovir treatment groups, the effect on hepatitis B virus DNA levels was evident within one week of therapy (p<0.0001) and was maintained throughout the 16-week treatment," said Trepo.
"All doses of famciclovir significantly reduced patients' levels of ALT. More importantly, the normalization of liver enzymes was sustained eight months after the 16-week treatment period in 50% of patients in the famciclovir 500 mg group," Trepo explained.
By the end of the study, there was significantly more seroconversion in the 500 mg treatment group than in the placebo group.
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